Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 74, Issue 4, Pages 349-355Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2012.08.013
Keywords
Polymerase chain reaction; Sepsis; Bacteremia; Blood culture; Molecular diagnostics; Bloodstream infection; FilmArray
Categories
Funding
- NIH/NIAID [1K23AI079401, 1U01AI082184]
- NIH/NICHD [K24HD047249, 1U01AI082482, 1U01AI074419, U01A1061611]
- CDC [1U18IP000303]
- NIH/NCRR [UL1RR025764]
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Sepsis is a leading cause of death. Rapid and accurate identification of pathogens and antimicrobial resistance directly from blood culture could improve patient outcomes. The FilmArray (R) (FA; Idaho Technology, Salt Lake City. UT, USA) Blood Culture (BC) panel can identify >25 pathogens and 4 antibiotic resistance genes from positive blood cultures in 1 h. We compared a development version of the panel to conventional culture and susceptibility testing on 102 archived blood cultures from adults and children with bacteremia. Of 109 pathogens identified by culture, 95% were identified by FA. Among 111 prospectively collected blood cultures, the FA identified 84 (91%) of 92 pathogens covered by the panel. Among 25 Staphylococcus aureus and 21 Enterococcus species detected, FA identified all culture-proven methicillin-resistant S. aureus and vancomycin-resistant enterococci. The FA BC panel is an accurate method for the rapid identification of pathogens and resistance genes from blood culture. (C) 2012 Elsevier Inc. All rights reserved.
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