Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 70, Issue 2, Pages 246-252Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2010.12.023
Keywords
Acinetobacter; Synergy; Colistin; Doripenem; Transplant
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Funding
- University of Pittsburgh School of Pharmacy
- University of Pittsburgh, Department of Medicine
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Extensively drug-resistant (XDR) Acinetobacter baumannii infections caused 91% (10/11) mortality in transplant recipients. Isolates were colistin-susceptible initially, but susceptibility decreased during therapy in 40% (4/10). We tested antibiotic combinations against XDR Acinetobacter in vitro and demonstrated positive interactions for carbapenem colistin. Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens. Published by Elsevier Inc.
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