Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 66, Issue 2, Pages 129-134Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2009.09.001
Keywords
Clostridium difficile; Toxin
Categories
Funding
- Meridian Bioscience
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Enzyme immunoassays are currently the most common tests used in the clinical laboratory for the detection of Clostridium difficile toxins; however, significant problems with their performance have recently been described. We prospectively reevaluated the Meridian Premier C. difficile toxin A/B assay with direct comparison to a 2-step algorithm that screened for C. difficile common antigen and compared cytotoxin and real-time polymerase chain reaction (PCR) as confirmatory procedures. The Premier assay lacked sufficient sensitivity, missing 25% of true-positive samples. PCR was the most sensitive method and the only procedure that allowed same day testing and reporting. (C) 2010 Elsevier Inc. All rights reserved.
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