Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 63, Issue 1, Pages 43-51Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2008.09.010
Keywords
Active tuberculosis; Mycobacterium tuberculosis
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Funding
- Sociedad Espanola de Patologia Respiratoria (SEPAR)
- Societat Catalana de Pneumologia (SOCAP)
- Fundacio Catalana de Pneumologia (FUCAP)
- Instituto de Salud Carlos III [RETIC RD06/0018]
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The objectives of the study were to assess the performance of the QuantiFERON-TB Gold In-Tube (QFN-G-IT) and the T-SPOT.TB tests in the immunodiagnosis of active tuberculosis (TB) in adult patients, and to Study the T-cell interferon gamma (IFN-gamma) responses during treatment and in patients who have recovered after curative treatment and self-healed TB patients. When only analyzing patients included at the beginning of treatment, the sensitivity was 83.3% for T-SPOT.TB and 69.4% for QFN-G-IT. In contrast, when evaluating patients during treatment, the sensitivity of the T-SPOT.TB and QFN-G-IT decreased to 69.8% and 48.8%, respectively. The response to the specific antigens increased after finishing the treatment compared with the values during the treatment. The T-SPOT.TB was more sensitive in diagnosing active TB than the QFN-G-IT. The IFN-gamma tests could be used as a complementary method in the diagnosis of active TB. (C) 2008 Elsevier Inc. All rights reserved.
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