Journal
DIABETOLOGIA
Volume 57, Issue 5, Pages 860-867Publisher
SPRINGER
DOI: 10.1007/s00125-014-3209-9
Keywords
Circadianmetabolism; FGFs; Glucose homeostasis; Nuclear receptors; Review
Categories
Funding
- US National Institutes of Health [DK057978, DK090962, HL088093, HL105278, CA014195, ES010337]
- Glenn Foundation for Medical Research
- Helmsley Charitable Trust
- Ipsen/Biomeasure
- Ellison Medical Foundation
- Kirschstein National Research Service Award (National Institute of Diabetes and Digestive and Kidney Diseases)
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The ability to adapt to cycles of feast and famine is critical for survival. Communication between multiple metabolic organs must be integrated to properly metabolise nutrients. By controlling networks of genes in major metabolic organs, nuclear hormone receptors (NHRs) play central roles in regulating metabolism in a tissue-specific manner. NHRs also establish daily rhythmicity by controlling the expression of core clock genes both centrally and peripherally. Recent findings show that many of the metabolic effects of NHRs are mediated through certain members of the fibroblast growth factor (FGF) family. This review focuses on the roles of NHRs in critical metabolic organs, including adipose tissue, liver and muscle, during the fed and fasted states, as well as their roles in circadian metabolism and downstream regulation of FGFs.
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