Related references
Note: Only part of the references are listed.cAMP inhibits mammalian target of rapamycin complex-1 and-2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
Jianling Xie et al.
CELLULAR SIGNALLING (2011)
Akt signalling in health and disease
Ingeborg Hers et al.
CELLULAR SIGNALLING (2011)
Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
Yanyun Gu et al.
DIABETES (2011)
Erythropoietin Protects Pancreatic beta-cell Line NIT-1 Cells Against Cytokine-Induced Apoptosis via Phosphatidylinositol 3-Kinase/Akt Signaling
Hongxia Shuai et al.
ENDOCRINE RESEARCH (2011)
mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets
Samantha F. Moore et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells
Claire E. Moore et al.
MOLECULAR ENDOCRINOLOGY (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
Lynda Elghazi et al.
DIABETES (2010)
Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism
Makiko Shimodahira et al.
JOURNAL OF ENDOCRINOLOGY (2010)
Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets
James D. Johnson et al.
CELL TRANSPLANTATION (2009)
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
Carson C. Thoreen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic β-Cells
Claire E. J. Moore et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Akt and PTEN: β-cell mass and pancreas plasticity
Lynda Elghazi et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2009)
Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells - Effects of pravastatin on the Akt survival pathway
Enrica Favaro et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells
Edith Gomez et al.
BIOCHEMICAL JOURNAL (2008)
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
Jingxiang Huang et al.
BIOCHEMICAL JOURNAL (2008)
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Tsuneo Ikenoue et al.
EMBO JOURNAL (2008)
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Valeria Facchinetti et al.
EMBO JOURNAL (2008)
Biphasic response of pancreatic β-cell mass to ablation of tuberous sclerosis complex 2 in mice
Yutaka Shigeyama et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
Latif Rachdi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Pathology of an islet transplant 2 years after transplantation: Evidence for a nonimmunological loss
R. Neal Smith et al.
TRANSPLANTATION (2008)
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Zhihong Zeng et al.
BLOOD (2007)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
Sirolimus is associated with reduced islet engraftment and impaired β-cell function
Nan Zhang et al.
DIABETES (2006)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov et al.
MOLECULAR CELL (2006)
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
I Ruvinsky et al.
GENES & DEVELOPMENT (2005)
Five-year follow-up after clinical islet transplantation
EA Ryan et al.
DIABETES (2005)
Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B
L Li et al.
DIABETOLOGIA (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
Q Wang et al.
DIABETOLOGIA (2004)
The development of new density gradient media for purifying human islets and islet-quality assessments
GC Huang et al.
TRANSPLANTATION (2004)
Glucose-stimulated protein synthesis in pancreatic β-cells parallels an increase in the availability of the translational ternary complex (eIF2-GTP•Met-tRNAi) and the dephosphorylation of eIF2α
E Gomez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: Local immunosuppression or islet toxicity?
NM Desai et al.
TRANSPLANTATION (2003)
Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets
E Bell et al.
DIABETES (2003)
Simvastatin induces activation of the serine-threonine-protein kinase Akt and increases survival of isolated human pancreatic islets
JL Contreras et al.
TRANSPLANTATION (2002)
Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic β-cells
ML McDaniel et al.
DIABETES (2002)
Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
H Cho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits β-cells and gradually increases the individual cell response
FC Jonkers et al.
DIABETES (2001)
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
M Pende et al.
NATURE (2000)
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
AMJ Shapiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Share Paper
