Journal
DIABETOLOGIA
Volume 55, Issue 8, Pages 2118-2127Publisher
SPRINGER
DOI: 10.1007/s00125-012-2567-4
Keywords
Blood glucose; Dietary intervention; HDL-cholesterol; LDL-cholesterol; Low-carbohydrate diet; Type 2 diabetes
Categories
Funding
- University Hospital of Linkoping Research Funds
- Linkoping University
- County Council of Ostergotland
- Diabetes Research Centre of Linkoping University
Ask authors/readers for more resources
The study aimed to compare the effects of a 2 year intervention with a low-fat diet (LFD) or a low-carbohydrate diet (LCD), based on four group meetings to achieve compliance. This was a prospective randomised parallel trial involving 61 adults with type 2 diabetes consecutively recruited in primary care and randomised by drawing ballots. Patients that did not speak Swedish could not be recruited. The primary outcomes in this non-blinded study were weight and HbA(1c). Patients on the LFD aimed for 55-60 energy per cent (E%) and those on LCD for 20 E% from carbohydrate. The mean BMI and HbA(1c) of the participants were 32.7 +/- 5.4 kg/m(2) and 57.0 +/- 9.2 mmol/mol, respectively. No patients were lost to follow-up. Weight loss did not differ between groups and was maximal at 6 months: LFD -3.99 +/- 4.1 kg (n = 31); LCD -4.31 +/- 3.6 kg (n = 30); p < 0.001 within groups. At 24 months, patients on the LFD had lost -2.97 +/- 4.9 kg and those on LCD -2.34 +/- 5.1 kg compared with baseline (p = 0.002 and p = 0.020 within groups, respectively). HbA(1c) fell in the LCD group only (LCD at 6 months -4.8 +/- 8.3 mmol/mol, p = 0.004, at 12 months -2.2 +/- 7.7 mmol/mol, p = 0.12; LFD at 6 months -0.9 +/- 8.8 mmol/mol, p = 0.56). At 6 months, HDL-cholesterol had increased with the LCD (from 1.13 +/- 0.33 mmol/l to 1.25 +/- 0.47 mmol/l, p = 0.018) while LDL-cholesterol did not differ between groups. Insulin doses were reduced in the LCD group (0 months, LCD 42 +/- 65 E, LFD 39 +/- 51 E; 6 months, LCD 30 +/- 47 E, LFD 38 +/- 48 E; p = 0.046 for between-group change). Weight changes did not differ between the diet groups, while insulin doses were reduced significantly more with the LCD at 6 months, when compliance was good. Thus, aiming for 20% of energy intake from carbohydrates is safe with respect to cardiovascular risk compared with the traditional LFD and this approach could constitute a treatment alternative. ClinicalTrials.gov NCT01005498 University Hospital of Linkoping Research Funds, Linkoping University, the County Council of A-stergotland, and the Diabetes Research Centre of Linkoping University.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available