Journal
DIABETOLOGIA
Volume 53, Issue 4, Pages 749-756Publisher
SPRINGER
DOI: 10.1007/s00125-009-1647-6
Keywords
Beta cell compensation; Beta cell function; Glucose tolerance; Hyperglycaemia; Insulin sensitivity; Pre-diabetes
Categories
Funding
- EU [QLG1-CT-2001-01252]
- AstraZeneca (Sweden)
- Merck Serono, France
Ask authors/readers for more resources
It is commonly thought that hyperglycaemia results from insufficient compensation of insulin secretion for insulin resistance. To verify this hypothesis, we assessed beta cell function and insulin sensitivity (IS) in a large cohort of volunteers with normal glucose tolerance (NGT) or impaired glucose regulation (IGR), i.e. impaired glucose tolerance or impaired fasting glucose. In men and women with NGT (n = 1,123) or IGR (n = 156) (age 44 +/- 8 years, BMI 25 +/- 4 kg/m(2), mean +/- SD) we measured: (1) IS by clamp; (2) insulin secretion rates (ISR) and beta cell glucose sensitivity (=slope of the insulin secretion/plasma glucose dose-response) by C-peptide deconvolution and OGTT modelling; and (3) acute insulin response to intravenous glucose. After controlling for centre, sex, age and BMI, fasting and total ISR were inversely related to IS in both groups, whereas beta cell glucose sensitivity was not. Acute insulin response was reciprocally related to IS in both groups, but the relationships were incompatible with inadequate compensation and significance was lost after controlling for fasting ISR. In IGR vs NGT, IS was impaired (92 [75] vs 133 [86] mu mol min(-1) [kg fat-free mass](-1) [nmol/l](-1), median [interquartile range], p < 0.0001) as was beta cell glucose sensitivity (69 [46] vs 119 [83] pmol min(-1) m(-2) [nmol/l](-1), p < 0.0001), whereas fasting and total ISR were increased (35% and 25%, respectively, p < 0.0001). In fully adjusted models, beta cell glucose sensitivity was the strongest determinant of OGTT glucose levels. Insulin resistance normally upregulates the secretory tone, with no evidence of defective compensation in IGR. In contrast, beta cell glucose sensitivity is independent of insulin resistance, but a key determinant of glucose tolerance. This suggests that hyperglycaemia results from an intrinsic beta cell defect rather than from inadequate compensation for insulin resistance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available