Journal
DIABETOLOGIA
Volume 52, Issue 5, Pages 830-833Publisher
SPRINGER
DOI: 10.1007/s00125-009-1297-8
Keywords
Asian; Association; Melatonin receptor 1B; SNP
Categories
Funding
- Swedish Research Council
- Wallenberg foundation
- Novo Nordisk
- Bergvall
- Pahlsson
- Nilsson-Ehle
- Tore Nilsson
- Ake Wiberg
- Crafoord
- The Swedish Diabetes Association
- National Science Foundation of China [30230380]
- National Nature Science foundation of China [30670999, 30711120573, 3030770854]
- The National Key Basic Research and Development Program [2002 CB713703]
- Key Project of Shanghai Commission for Science and Technology [04dz19504]
Ask authors/readers for more resources
Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in populations of European ancestry. In the present study, we investigated whether a single MTNR1B polymorphism was associated with type 2 diabetes in Han Chinese individuals, to elucidate whether this is a cross-populational effect. The MTNR1B variant rs10830963 was genotyped in 1,165 type 2 diabetic patients and 1,105 normoglycaemic control individuals of southern Han Chinese ancestry who were residents of the metropolitan area of Shanghai. The risk of developing type 2 diabetes was calculated using a logistic regression model adjusted for age, sex and BMI. A possible association with fasting plasma glucose was analysed in the normoglycaemic control individuals using a multiple linear regression analysis with adjustments for age, sex and BMI. The genetic variant rs10830963 was associated with an increased risk of type 2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele. A common variant in the MTNR1B gene is associated with an increased risk of type 2 diabetes and increased fasting plasma glucose in Han Chinese, suggesting an important role for this polymorphism in populations of different ethnic and environmental backgrounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available