Journal
DIABETIC MEDICINE
Volume 29, Issue 11, Pages E409-E416Publisher
WILEY
DOI: 10.1111/j.1464-5491.2012.03759.x
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Funding
- Wellcome Trust [G061895]
- Medical Research Council [G0001164]
- National Institute for Health Research (NIHR) Health Technology Assessment Programme [08/116/300]
- National Health Service R&D support funding
- National Institute for Health Research
- Department of Health NIHR Programme Grant funding scheme [RP-PG-0606-1259]
- National Health Services
- Danish Council for Strategic Research
- Danish Research Foundation for General Practice
- Novo Nordisk Foundation
- Danish Centre for Evaluation and Health Technology Assessment
- National Board of Health
- Danish Medical Research Council
- Aarhus University Research Foundation
- Novo Nordisk AS
- Novo Nordisk Scandinavia AB
- Novo Nordisk UK
- ASTRA Denmark
- Pfizer Denmark
- GlaxoSmithKline Pharma Denmark
- Servier Denmark A/S
- HemoCue Denmark A/S
- MRC [MC_U106179474, G0001164] Funding Source: UKRI
- Medical Research Council [G0001164, MC_U106179474, MC_U106179471] Funding Source: researchfish
- National Institute for Health Research [08/116/300, RP-PG-0606-1272, RP-DG-1210-10183, RP-PG-0606-1259] Funding Source: researchfish
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Aims To describe the total cardiovascular burden (cardiovascular morbidity or mortality, revascularization or non-traumatic amputation) in individuals with screen-detected diabetes in the ADDITION-Europe trial and to quantify the impact of the intervention on multiple cardiovascular events over 5 years. Methods In a pragmatic, cluster-randomized, parallel-group trial in four centres (Denmark; Cambridge, UK; the Netherlands; and Leicester, UK), 343 general practices were randomized to screening plus routine care (n = 1379 patients), or screening and promotion of target-driven, intensive treatment of multiple risk factors (n = 1678). We estimated the effect of the intervention on multiple cardiovascular events after diagnosis of diabetes using the Wei, Lin and Weissfeld method. Results Over 5.3 years, 167 individuals had exactly one cardiovascular event, 53 exactly two events, and 18 three or more events. The incidence rates (95% CI) of first events and any event per 1000 person-years were 14.6 (12.816.6) and 20.4 (18.222.6), respectively. There were non-significant reductions in the risk of a first (hazard ratio 0.83, 95% CI 0.651.05) and second primary endpoint (hazard ratio 0.70, 95% CI 0.431.12). The overall average hazard ratio for any event was 0.77 (95% CI 0.581.02). Conclusions Early intensive multifactorial treatment was not associated with a significant reduction in total cardiovascular burden at 5 years. Focusing on first events in cardiovascular disease prevention trials underestimates the total cardiovascular burden to patients and the health service.
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