Journal
DIABETIC MEDICINE
Volume 29, Issue 9, Pages 1184-1190Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1464-5491.2012.03613.x
Keywords
albuminuria; 1; 5-anhydroglucitol; retinopathy; Type 2 diabetes mellitus
Categories
Funding
- Health Promotion Funds from the Korean Ministry for Health, Welfare, and Family Affairs
- Welfare Bureau of Seoul Metropolitan Government
Ask authors/readers for more resources
Diabet. Med. 29, 1184-1190 (2012) Abstract Aims To determine whether there is a relationship between 1,5-anhydroglucitol (1,5-AG), a marker of postprandial hyperglycaemia and glycaemic variability, and the presence of diabetic retinopathy and albuminuria in patients with Type 2 diabetes. Methods Five hundred and sixty-seven patients with Type 2 diabetes (serum creatinine < 133 mu mol/l), who were enrolled in the Seoul Metro-City Diabetes Prevention Program (SMC-DPP), were cross-sectionally assessed by multivariate logistic regression analysis. Results After controlling for age, sex, binary HbA1c levels, duration of diabetes, triglyceride, systolic blood pressure, smoking status, history of hypertension and dyslipidaemia, and the use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker medication, the odds ratios (95% CI) of diabetic retinopathy were 2.86 (1.127.25) for the first (lowest) quartile of 1,5-anhydroglucitol, 2.87 (1.256.61) for the second quartile and 0.88 (0.352.22) for the third quartile compared with the fourth quartile (P for trend = 0.010). Conversely, the associations between 1,5-anhydroglucitol and clinical albuminuria were non-significant after adjustment. Subjects with low 1,5-anhydroglucitol (< 10.0 mu g/ml) were more likely to experience diabetic retinopathy than those with high 1,5-anhydroglucitol (>= 10.0 mu g/ml) under moderate glucose control (HbA1c < 8%, 64 mmol/mol) and there were no significant differences in the prevalence of diabetic retinopathy between the subgroup with HbA1c < 8% (64 mmol/mol) and low 1,5-anhydroglucitol and the subgroup with HbA1c = 8% (64 mmol/mol). Conclusions 1,5-Anhydroglucitol levels show close associations with diabetic retinopathy, especially among patients under moderate glucose control, but not with albuminuria. These results suggest that 1,5-anhydroglucitol might be a complementary marker for targeting higher risk group.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available