Journal
DIABETIC MEDICINE
Volume 29, Issue 10, Pages e377-e381Publisher
WILEY
DOI: 10.1111/j.1464-5491.2012.03737.x
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Funding
- Novo Nordisk
- Swedish Research Council
- Swedish Heart Lung Foundation
- Skane Health Authority
- EX-GENESIS
- UMAS Fonder
- Magn. Bergvalls Foundation
- Syskonen Svenssons Foundation
- NuGo
- Wallenberg Foundation
- National Heart, Lung and Blood Institute [K99HL098459]
- Sigrid Juselius Foundation
- Folkhalsan Foundation
- Finnish Ministry of Health
- Novo Nordisk Fonden [NNF11OC1014855] Funding Source: researchfish
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Diabet. Med. 29, e377e381 (2012) Abstract Aims Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and insulin action. Muscle telomere length reflects the myocytes exposure to harmful environmental factors. Leukocyte telomere length is considered a marker of muscle telomere length and is used in epidemiologic studies to assess associations with ageing-related diseases where muscle physiology is important. However, the extent to which leucocyte and muscle telomere length are correlated is unknown, as are their relative correlations with glucose and insulin concentrations. The purpose of this study was to determine the extent of these relationships. Methods Leucocyte and muscle telomere length were measured by quantitative real-time polymerase chain reaction in participants from the Malmo Exercise Intervention (n = 27) and the Prevalence, Prediction and Prevention of DiabetesBotnia studies (n = 31). Participants in both studies were free from Type 2 diabetes. We assessed the association between leucocyte telomere length, muscle telomere length and metabolic traits using Spearmen correlations and multivariate linear regression. BlandAltman analysis was used to assess agreement between leucocyte and muscle telomere length. Results In age-, study-, diabetes family history- and sex-adjusted models, leucocyte and muscle telomere length were positively correlated (r = 0.39, 95% CI 0.150.59). Leucocyte telomere length was inversely associated with 2-h glucose concentrations (r = -0.58, 95% CI -1.0 to -0.16), but there was no correlation between muscle telomere length and 2-h glucose concentrations (r = 0.05, 95% CI -0.35 to 0.46) or between leucocyte or muscle telomere length with other metabolic traits. Conclusions In summary, the current study supports the use of leucocyte telomere length as a proxy for muscle telomere length in epidemiological studies of Type 2 diabetes aetiology.
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