Journal
DIABETES-METABOLISM RESEARCH AND REVIEWS
Volume 29, Issue 6, Pages 452-462Publisher
WILEY
DOI: 10.1002/dmrr.2412
Keywords
IGF-I; IGFBP-3; metabolic syndrome; type 2 diabetes mellitus; Study of Health in Pomerania (SHIP)
Categories
Funding
- German Federal Ministry of Education and Research (BMBF) [01ZZ0403, 01ZZ0103, 01GI0883]
- Ministry for Education, Research and Cultural Affairs
- Ministry of Social Affairs of the Federal State of Mecklenburg-West Pomerania
- Novo Nordisc
- Pfizer
Ask authors/readers for more resources
Background A previous study showed an inverse association between the insulin-like growth factor I (IGF-I) and the risk of impaired glucose tolerance or diabetes mellitus. Moreover, myocardial infarction patients with high baseline IGF-I levels had a lower risk of diabetes mellitus. These data suggested a protective effect of IGF-I against the development of metabolic syndrome. However, there are no longitudinal data regarding IGF-I and metabolic syndrome. The aim of the present study was to investigate the longitudinal association between IGF-I and metabolic syndrome. Methods Data from the population-based Study of Health in Pomerania, Germany, were used for cross-sectional (n=3903) and longitudinal (n=2143) analyses (5-year follow-up). Metabolic syndrome was defined by three or more of the following five components: abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure and elevated nonfasting glucose. Serum IGF-I and IGF binding protein 3 (IGFBP-3) were determined by chemiluminescence immunoassays. Logistic and Poisson regression analyses were performed to determine associations. Results In cross-sectional analyses high IGFBP-3 as well as high and low IGF-I/IGFBP-3 ratio levels were associated with prevalent metabolic syndrome. In longitudinal analyses, the direction of the relation changed: men but not women with high IGF-I or IGF-I/IGFBP-3 ratio levels had an increased, whereas men with low levels had a decreased risk of incident metabolic syndrome. Conclusion In concordance with previous studies, our cross-sectional analyses showed a relation between low IGF-I/IGFBP-3 ratio and the prevalence of metabolic syndrome. In contrast, the longitudinal analyses indicated that a high IGF-I level was a risk marker for incident metabolic syndrome. Copyright (c) 2013 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available