Journal
DIABETES-METABOLISM RESEARCH AND REVIEWS
Volume 26, Issue 7, Pages 507-519Publisher
WILEY
DOI: 10.1002/dmrr.1112
Keywords
diabetes mellitus; cognitive functioning; dementia; vascular risk factors; imaging; neuropsychological assessment
Categories
Funding
- Dutch Diabetes Research Foundation [2003.01.004]
- Utrecht University
Ask authors/readers for more resources
People with diabetes mellitus are at increased risk of cognitive dysfunction and dementia. This review explores the nature and severity of cognitive changes in patients with type 2 diabetes. Possible risk factors such as hypo- and hyperglycemia, vascular risk factors, micro- and macrovascular complications, depression and genetic factors will be examined, as well as findings from brain imaging and autopsy studies. We will show that type 2 diabetes is associated with modest cognitive decrements in non-demented patients that evolve only slowly over time, but also with an increased risk of more severe cognitive deficits and dementia. There is a dissociation between these two 'types' of cognitive dysfunction with regard to affected age groups and course of development. Therefore, we hypothesize that the mild and severe cognitive deficits observed in patients with type 2 diabetes reflect separate processes, possibly with different risk factors and aetiologies. Copyright (C) 2010 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available