Efficacy of low-level light therapy for treatment of diabetic foot ulcer: A systematic review and metaanalysis of randomized controlled trials

Aims: The goal of this systematic review and meta-analysis based on seven Randomized control trials (RCTs) is to examine whether Low-level light therapy (LLLT) is effective at healing diabetic foot ulcer (DFU) and to provide evidence-based recommendations and clinical guidelines for the future clinical treatment of DFUs. Methods: Medline, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for studies published up to June 30, 2017, without language or data restrictions. RCTs that investigated the use of LLLT for DFU treatment were included. Standard methods of meta-analysis were performed to evaluate outcomes of LLLT on the healing of DFU. Results: Seven RCTs involving 194 participants were eligible for this systematic review and meta-analysis. The results of meta-analysis showed that LLLT has emerged as a potential noninvasive treatment for DFUs, as LLLT was found to effectively reduce the ulcer area [weighted mean difference (WMD) 34.18, 95% confidence intervals (CI) 19.38-48.99, P < 0.00001], improve the complete healing rate [odds ratio (OR) 6.72, 95% CI 1.99-22.64, P = 0.002]. Qualitative analysis of the included RCTs found that LLLT also played a role in the treatment of DFUs through promoting rapid granulation formation and shortening ulcer closure time, as well as alleviating foot ulcer pain. None of the treatment-related adverse event was reported. Conclusions: LLLT was recognized as a potential method in the comprehensive treatment of DFUs. Further well designed and high-quality studies are required to confirm the role of LLLT in the management of DFUs. (C) 2018 Elsevier B.V. All rights reserved.