Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 104, Issue 3, Pages 297-322Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2014.02.014
Keywords
Type 2 diabetes; Glucose reabsorption; SGLT2 inhibitors; Dapagliflozin; Canagliflozin; Empagliflozin
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The kidney plays an important role in glucose homeostasis via its production, utilization, and, most importantly, reabsorption of glucose from glomerular filtrate which is largely mediated via the sodium glucose co-transporter 2 (SGLT2). Pharmacological inhibition of SGLT2 increases urinary glucose excretion and decreases plasma glucose levels in an insulin-independent manner. Agents that inhibit SGLT2 represent a novel class of drugs, which has recently become available for treatment of type 2 diabetes. This article summarizes the rationale for use of these agents and reviews available clinical data on their efficacy, safety, and risks/benefits. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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