Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 100, Issue 2, Pages 265-271Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2013.03.013
Keywords
Fructose; Cardiovascular risk factors; Triglycerides; Adolescents; Type 1 diabetes
Categories
Funding
- Centers for Disease Control and Prevention [00097, DP-05-069, DP-10-001]
- National Institute of Diabetes and Digestive and Kidney Diseases
- Kaiser Permanente Southern California [U48/CCU919219, U01 DP000246, U18DP002714]
- University of Colorado Denver [U48/CCU819241-3, U01 DP000247, U18DP000247-06A1]
- Kuakini Medical Center [U58CCU919256, U01 DP000245]
- Children's Hospital Medical Center (Cincinnati) [U48/CCU519239, U01 DP000248, 1U18DP002709]
- University of North Carolina at Chapel Hill [U48/CCU419249, U01 DP000254, U18DP002708-01]
- University of Washington School of Medicine [U58/CCU019235-4, U01 DP000244, U18DP002710-01]
- Wake Forest University School of Medicine [U48/CCU919219, U01 DP000250, 200-2010-35171]
- NIH/NCRR [UL1RR029882]
- Children's Hospital and Regional Medical Center [M01RR00037]
- Colorado Pediatric General Clinical Research Center [M01 RR00069]
- Barbara Davis Center at the University of Colorado at Denver [DERC NIH P30 DK57516]
- NIH/NCRR at the University of Cincinnati [1UL1RR026314-01]
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Aims: High consumption of dietary fructose has been shown to contribute to dyslipidemia and elevated blood pressure in adults, but there are few data in youth, particularly those at greater risk of cardiovascular disease (CVD). The aim of this study was to examine the association between fructose intake and CVD risk factors in a diverse population of youth with type 1 diabetes (T1D). Methods: This was a cross-sectional analysis of data from the SEARCH for Diabetes in Youth study, including 2085 youth ages 10-22 years with T1D, of which 22% were racial/ethnic minority and 50% were female. A semi-quantitative food frequency questionnaire was used to assess intake. Results: Median daily fructose consumption was 7.9% of total calories. Fructose intake was positively associated with triglycerides (p <.01), but not with total cholesterol, LDL-cholesterol, HDL-cholesterol, or blood pressure after adjustment for physical activity and socio-demographic, clinical, and dietary covariates. An increase in fructose intake of 22 g (equivalent to a 12 oz can of soda) was associated with 23% higher odds of borderline/high versus low triglycerides (p <.005). Conclusion: These data suggest that children with T1D should moderate their intake of fructose, particularly those with borderline or high triglycerides. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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