4.5 Article

Atorvastatin ameliorates podocyte injury in patients with type 2 diabetes complicated with dyslipidemia

Journal

DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 100, Issue 1, Pages E26-E29

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2012.12.018

Keywords

Statin; Atorvastatin; Rosuvastatin; Diabetic nephropathy; Podocyte; Urinary podocyte

Funding

  1. Ministry of Education, Culture, Sports, Science and Technology
  2. Ministry of Health, Labor and Welfare
  3. Grants-in-Aid for Scientific Research [24591312, 23591297] Funding Source: KAKEN

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We examined the effects of atorvastatin on urinary podocyte excretion. Thirteen patients with type 2 diabetes receiving 2.5 mg of rosuvastatin were recruited and the medication was switched to 10 mg of atorvastatin for a 24-week period. With the switch to atorvastatin, the urinary excretion of podocytes was significantly reduced. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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