☆ 4.5 Article

Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population

DIABETES RESEARCH AND CLINICAL PRACTICE (2012)

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Journal

DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 95, Issue 2, Pages E37-E40

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2011.11.002

Keywords

CDKAL1; CDKN2A/2B; Diabetes; Haplotypes; Replication studies

Categories

Endocrinology & Metabolism

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We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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