Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 97, Issue 1, Pages 105-111Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2012.02.011
Keywords
DPP-IV; GLP-1; In silico; In vitro; In vivo; Naringin
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The incretin based therapies are emerging class of antidiabetic drugs having two categories one is glucagone like peptide-1 (GLP-1) agonists and another one is dipeptidyl peptidase (CD26; DPP-IV) inhibitors. However, in DPP-IV inhibitors category only few compounds are commercially available and also having some undesirable effects. Therefore, in the present work we tried to explore a naturally occurring compound naringin for its potential DPP-IV inhibition and antidiabetic potential. It is noteworthy that this compound is abundantly present in the peels of Orange and thus may provide cost effective treatment for diabetes especially type 2 diabetes mellitus. In the present study we have conducted virtual docking study and observed tight binding of naringin, as shown by higher negative values of H Bond lengths, while in vitro DPP-IV inhibition assay has also shown better inhibition by naringin. In vivo study, in response to 10 days administration of 40 mg/kg of naringin twice daily to Wistar albino rats, inhibited the serum levels of DPP-IV activity, random glucose concentration with concomitant increase in insulin levels. All the comparisons were made with the standard commercially available drug sitagliptin. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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