Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 97, Issue 2, Pages 258-266Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2012.02.016
Keywords
Liraglutide; Glucagon-like peptide-1; Appetite; Energy intake; Gastric emptying
Categories
Funding
- Novo Nordisk (the manufacturer of Victoza(R))
- Novo Nordisk A/S, Denmark
Ask authors/readers for more resources
Aims: Liraglutide reduces bodyweight in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate the mechanisms underlying this effect. Methods: The comparative effects of liraglutide, glimepiride and placebo on energy intake, appetite, nausea, gastric emptying, antral distension, bodyweight, gastrointestinal hormones, fasting plasma glucose and resting energy expenditure (REE), were assessed in subjects with T2DM randomised to treatment A (liraglutide-placebo), B (placebo-glimepiride) or C (glimepiride-liraglutide). Assessments were performed at the end of each 4-week treatment period. Results: Energy intake was less (NS) with liraglutide vs placebo and glimepiride, and 24-h REE was higher (NS) with liraglutide vs placebo and glimepiride. Fasting hunger was less (p = 0.01) with liraglutide vs placebo and glimepiride, and meal duration was shorter with liraglutide (p = 0.002) vs placebo. Paracetamol AUC(0-60min) and C-max were less (p < 0.01) and fasting peptide YY was lower (p <= 0.001) after liraglutide vs placebo and glimepiride. Bodyweight reductions of 1.3 and 2.0 kg were observed with liraglutide vs placebo and glimepiride (p < 0.001). There were no differences on antral distension, nausea, or other gastro-intestinal hormones. Conclusion: Liraglutide caused decreased gastric emptying and increased reduction in bodyweight. The mechanisms of the liraglutide-induced weight-loss may involve a combined effect on energy intake and energy expenditure. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available