Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 93, Issue 1, Pages 70-76Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2011.03.018
Keywords
Anti-diabetic effects; Ishige okamurae extract; C57BL/KsJ-db/db mice
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Funding
- Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea
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We investigated the effect of Ishige okamurae extract on blood glucose level and insulin resistance in C57BL/-KsJ-db/db mice. We administered a standard AIN-93G diet with or without IOE to the animals for 6 weeks. After 6 weeks, blood glucose level was improved and blood glycosylated hemoglobin levels were lowered in sample group mice as compared to those in the diabetic control group mice. Hyperinsulinemia was reduced in the I. okamurae extract group mice with type 2 diabetes. With regard to hepatic glucose metabolic enzyme activities, glucokinase activity was enhanced in the IOE group mice, while glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities in the IOE group mice were significantly lowered than those in the diabetic control group mice. In addition, the hepatic glycogen content was elevated in the IOE group as compared to that in the diabetic control group. The homeostatic index of insulin resistance was lower in the I. okamurae extract group mice than in the diabetic control group mice. These results suggest that a dietary supplement of I. okamurae extract lowers the blood glucose level by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance. (C) 2011 Published by Elsevier Ireland Ltd.
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