Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 87, Issue 2, Pages 211-218Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2009.09.029
Keywords
Aspirin; Diabetes mellitus; Meta-analysis
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Funding
- National Basic Research Program of China [2006CB503803, 2005CB523302]
- 863 Program of Science and Technology Ministry [2006AA0ZA406]
- National Natural Science Fundation of China [30725036]
- Key Projects in the National Science & Technology Pillar Program in the Eleventh Five-year Plan Period [2006BAI01A04]
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Background: To systematically review trials concerning the benefit and risk of aspirin therapy for primary prevention of cardiovascular events in patients with diabetes mellitus. Methods: We searched MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials. Eligible studies were prospective, randomized controlled trials of aspirin therapy for primary cardiovascular prevention in patients with diabetes with follow-up duration at least 12 months. Results: 7 trials included 11,618 individuals with diabetes. Aspirin therapy was not associated with a statistically significant reduction in major cardiovascular events (relative risk [RR] 0.92, 95% confidence interval [CI] 0.83-1.02, p = 0.11). Aspirin use also did not significantly reduce all-cause mortality (0.95, 95% CI 0.85-1.06; p = 0.33), cardiovascular mortality (0.95, 95% Cl 0.71-1.27; p = 0.71), stroke (0.83, 95% CI 0.63-1.10; p = 0.20), or myocardial infarction (MI) (0.85, 95% CI 0.65-1.11; p = 0.24). There was no significant increased risk of major bleeding in aspirin group (2.46, 95% CI 0.70-8.61; p = 0.16). Meta-regression suggested that aspirin agent could reduce the risk of stroke in women and MI in men. Conclusions: In patients with diabetes, aspirin therapy did not significantly reduce the risk of cardiovascular events without an increased risk of major bleeding, and showed sex-specific effects on MI and stroke. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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