Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 86, Issue 2, Pages 146-151Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2009.08.012
Keywords
Survival; Age at onset; Age at death; Disease duration; Causes of death; Prognosis
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Aims: To investigate the survival with diabetes inpatients treated with insulin from diagnosis. Subjects and methods: We analyzed 845 subjects, 55.9% males, registered at I. Pavel Bucharest Diabetes Centre, insulin-treated from diagnosis, aged <40 years and deceased between 1946 and 2005. We divided the subjects in two groups by age at diagnosis: group A <18 years and group B 18-39.99 years. We used 20 years time periods for year of death: 1946-1965, 1966-1985 and 1986-2005. Results: The mean age at diabetes onset was 30.36 +/- 8.04 years, disease duration at death 20.98 +/- 11.62 years and age at death 51.34 +/- 14.37 years. The mean increase in survival with diabetes was 19.3 years for group A and 15.9 years for group B. There was a significant decrease in infections in both groups. The increase in coronary heart diseases and stroke is evident only in group B. Conclusions: We found no changes in age at onset, which combined with an increase in survival with diabetes lead to a significant increase in age at death over the six decades analyzed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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