Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 80, Issue 1, Pages 102-107Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2007.11.006
Keywords
diabetes; obesity; renal insufficiency; creatinine clearance; glomerular filtration rate
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Background: It is crucial to estimate renal function in diabetic patients. However, formulas are inadequate in this population whereas creatinine clearance (C-cr) on a 24-h urine collection may be valuable only if we can improve its reproducibility. Objective: To evaluate in diabetic patients whether standardised procedures of 24-h urine collection improve the day-to-day variability in creatinine urinary excretion and the subsequent precision of the measured C-cr. Methods: The C-cr from two consecutive 24-h urine collections was measured in 201 consecutive diabetic inpatients. Procedures of 24-h urine collection were standardised, and implementation was supervised at a diabetes clinic. Results: Pearson's correlation coefficients of the two 24-h creatinine urinary excretion were significant (r(2) = 0.64 in women and r(2) = 0.65 in men, p < 0.0001) but the daily variability in creatinine urinary excretion was high (14.9% in women and 17.4% in men). As a consequence, the agreement between the two consecutive measurements of Cc, was poor. First, Bland-Altman plots showed large 95% limits of agreement (-34.3 to 34.6 mL/min//1.73 m(2) in women and -39.0 to 52.0 mL/min/1.73 m(2) in men). Secondly, there was a poor agreement for classifying patients according to the National Kidney Foundation classification > 90, 60-89.9, 30-59.9, and < 30 mL/min/1.73 m(2) (Kappa coefficients = 0.61, 0.42, 0.65, and 0.74, respectively). Conclusions: Despite standardised procedures of 24-h urine collection, day-to-day variability in creatinine urinary excretion in adult diabetic men and women remains important, and may lead to misclassification of renal disease. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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