Journal
DIABETES OBESITY & METABOLISM
Volume 14, Issue 7, Pages 596-600Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1463-1326.2012.01567.x
Keywords
acute renal failure; DPP-4 inhibitors; exenatide; GLP-1 agonists; sitagliptin
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Funding
- Medco Health Solutions, Inc.
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Aim: This study evaluated whether the risk of acute renal failure (ARF) increases with exenatide and sitagliptin use. Methods: A retrospective cohort study of a large medical and pharmacy claims database was performed. Data for 4 91 539 patients were analysed. Cox proportional hazard models were used to compare the risk of ARF between diabetic and non-diabetic subjects and between diabetic patients treated with exenatide, sitagliptin and control medications. Results: Adjusted Cox analyses showed diabetic subjects had a higher risk of ARF [HR 1.51, confidence interval (CI) 1.261.81, p < 0.001] than non-diabetic controls. Compared with diabetic controls, neither exenatide (HR 0.77, CI 0.421.41, p = 0.40) nor sitagliptin (HR 1.17, CI 0.821.65, p = 0.39) increased the risk of ARF. Conclusion: Our study revealed an increased incidence of ARF in diabetic versus non-diabetic patients but no association between use of exenatide or sitagliptin and ARF. Because of the limitations of this observational analysis, we cannot exclude the possibility of a very small increased risk.
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