Journal
DIABETES OBESITY & METABOLISM
Volume 12, Issue 9, Pages 790-797Publisher
WILEY
DOI: 10.1111/j.1463-1326.2010.01236.x
Keywords
clinical trial; dietary intervention; exercise; insulin resistance; primary care
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Funding
- Japan Society for the Promotion of Science, Japan [20591065]
- Japan Diabetes Foundation
- Health Promotion Project of the National Health Insurance
- town of Ueki
- Grants-in-Aid for Scientific Research [20591065] Funding Source: KAKEN
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Methods: Ninety-eight subjects who had at least one component of MS were randomized into standard intervention (SI) (4-month intervention; n = 50) and extended intervention (EI) (10-month intervention; n = 48) groups, and 39 subjects were followed up for a control group. The effects of intervention were evaluated after 10, 22 and 34 months. Results: At month 10, the standard and EI groups showed improved body mass index (BMI) (SI, -0.28; EI, -0.47; control, -0.09), high-density lipoprotein (HDL) cholesterol, fasting plasma glucose and A1c and a decreased mean number of components of MS (SI, -0.37; EI, -0.51; control, 0.08). At month 34, the effects on BMI (SI, -0.66; EI, -0.60; control, -0.05) and HDL-cholesterol were sustained for both the intervention groups. In controls, the increases in fasting plasma glucose and the mean number of components of MS from the baseline to month 34 were greater than those in the standard and EI groups. Whole body insulin sensitivity index and hepatic insulin resistance index were also improved at month 10. Conclusions: Group-based lifestyle intervention could be an efficient way to prevent MS. Its effects were sustainable, at least in part, for 2 years. These effects may be mediated by an improvement in insulin sensitivity.
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