4.7 Article

Exendin-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic β-cell line

Journal

DIABETES OBESITY & METABOLISM
Volume 11, Issue 10, Pages 939-946

Publisher

WILEY
DOI: 10.1111/j.1463-1326.2009.01067.x

Keywords

CaMKK; CaMKIV; exendin-4; GLP-1; glucokinase

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Aim Glucokinase (GK) in pancreatic beta cells is thought to be involved in insulin secretion and glucose homeostasis. This study investigates whether the long-acting agonist of the glucagon-like peptide 1, namely exendin-4, mediates stimulatory effects on GK gene expression through the Ca

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