Journal
DIABETES OBESITY & METABOLISM
Volume 10, Issue -, Pages 119-127Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1463-1326.2008.00955.x
Keywords
integrins; laminin; lutheran; niche
Categories
Funding
- European Union [036903]
- Academy of Finland
- Juvenile Diabetes Research Foundation
- Sigrid Juselius Foundation
- Finnish Diabetes Research Foundation
- EVO [TYH6269]
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Basement membranes (BMs) are an important part of the physiological microenvironment of pancreatic islet cells. In Moose islets. P-cells interact directly with BMs of capillary endothelial cells. We have shown that in the human islets, the capillaries are surrounded by a double BM both in foetal and adult tissues. The endocrine islet cells are facing a BM that is separate from the endothelia. Laminins are the functionally most important component of BMs. The only laminin isoform present in the human endocrine islet BM is laminin-511 (previously known as laminin 10). The islet cells facing this BM have a strong and polarized expression of Lutheran glycoprotein, which is a well-known receptor for the laminin 75 chain. Dispersed human islet cells adhere to purified ,human laminin-511 and the binding is equally effectively blocked by a soluble form of Lutheran as by antibody against integrin beta 1. Our results reveal unique features of the BM structure of human islets, different from rodents. This information has potentially important implications for the generation of an optimal microenvironment for beta-cell function, proliferation and differentiation.
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