Journal
DIABETES CARE
Volume 37, Issue 6, Pages 1741-1744Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc13-2612
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Funding
- National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development [HD-41890-10, HD-41906-10, HD-41908-10, HD-41915, HD-41918, HD-56526, UL1-RR-024992, UL1-RR-024139, UL1-RR-024979, UL1-RR-025744, UL1-RR-024150]
- Pediatric Endocrine/Diabetes Physician Scientists [K12-DK-094714-01]
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OBJECTIVE To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2). Twenty nondiabetic (ND) control children were also studied. RESULTS In T1D children, MMTT-stimulated increases in glucagon were significantly greater than that in ND children (median increments: year 1, 21 pg/mL [16-30]; year 2, 25 pg/mL [16-30]; ND, 9 pg/mL [5-16]; P = 0.001 and P < 0.001, respectively). CONCLUSIONS In comparison with ND control children, exaggerated plasma glucagon responses to mixed-meal feedings are observed in youth with T1D within the first 2 years of diagnosis. Further studies to determine whether suppression of these abnormal responses may help to improve glycemic control are warranted.
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