Journal
DIABETES CARE
Volume 36, Issue 11, Pages 3815-3817Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc13-0203
Keywords
-
Categories
Funding
- JDRF
- American Diabetes Association
Ask authors/readers for more resources
OBJECTIVEEvidence supporting an association between complement (C) and type 1 diabetes (T1D) includes the identification of C-fixing islet cell autoantibodies in T1D sera and genetic associations with the major histocompatibility complex III C4 region on chromosome 6. Therefore, we investigated whether C activation was present in pancreata from those with or at increased risk (positive for T1D associated autoantibodies) for T1D.RESEARCH DESIGN AND METHODSImmunohistochemical techniques were used to measure the C degradation product C4d in organ donor pancreata from patients with T1D and type 2 diabetes and autoantibody-positive and autoantibody-negative subjects.RESULTSMedian C4d antigen density differed across the groups (P < 0.0001) and was highest in patients with T1D. C4d immunostaining localized to the blood vessel endothelium and extracellular matrix surrounding blood vessels and exocrine ducts. Receiver operating characteristic analysis resulted in 81.8% sensitivity and 94.4% specificity for C4d staining.CONCLUSIONSThese data suggest that C activation is occurring within pancreata from patients with T1D and C4d may be a biomarker for T1D.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available