Journal
DIABETES CARE
Volume 36, Issue 2, Pages 410-414Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc12-0220
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [KFO 152, FA476/4-1]
- Federal Ministry of Education and Research (BMBF), Germany [FKZ 01EO1001, K7-3, K7-9, K7-31]
- Deutsche Hochdruckliga e.V.
- Medical Faculty, University of Leipzig
- BMBF, Germany [FKZ 01EO1001]
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OBJECTIVE-Progranulin has recently been introduced as a novel adipokine inducing insulin resistance and obesity. In the current study, we investigated renal elimination, as well as association of the adipokine with markers of the metabolic syndrome. RESEARCH DESIGN AND METHODS-Progranulin serum levels were quantified by enzyme-linked immunosorbent assay and correlated to anthropometric and biochemical parameters of renal function and glucose and lipid metabolism, as well as inflammation, in 532 patients with stages 1-5 of chronic kidney disease (CKD). RESULTS-Median serum progranulin levels adjusted for age, sex, and BMI were significantly different between CKD stages with highest values detectable in stage 5 (stage 1, 58.3 mu g/L; stage 2, 63.0 mu g/L; stage 3, 65.4 mu g/L; stage 4, 68.8 mu g/L; and stage 5, 90.6 mu g/L). Furthermore, CKD stage was the strongest independent predictor of circulating progranulin in our cohort. In addition, high-sensitivity interleukin-6 and adiponectin remained significantly and independently correlated with the adipokine. CONCLUSIONS-We demonstrate that progranulin serum levels increase with deteriorating renal function. These findings are in accordance with the hypothesis that renal clearance is a major elimination route for circulating progranulin. Furthermore, the adipokine is positively and independently associated with markers of inflammation and adiponectin. Diabetes Care 36:410-414, 2013
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