Journal
DIABETES CARE
Volume 35, Issue 7, Pages 1462-1465Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc12-0052
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Funding
- Juvenile Diabetes Research Foundation postdoctoral fellowship
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OBJECTIVE-The advent of sensor-augmented pump therapy with a low-glucose suspend (LGS) function (Medtronic Paradigm Veo System), allowing insulin to be automatically suspended for up to 2 h when sensor glucose falls below a preset threshold, has the potential to reduce the duration of hypoglycemia. In this article, we analyzed blood glucose profiles following a full 2-h insulin suspension activated by the LGS function, as well as examined different patterns of use among patients. RESEARCH DESIGN AND METHODS-Data from a cohort of participants using the Veo System for up to 6 months were analyzed to determine the time and duration of insulin suspension activated by the LGS function. We further evaluated overnight suspend events with no patient response occurring prior to 3:00 A.M., which allowed us to determine the pattern of sensor glucose values with no patient intervention during and after the period of insulin suspension. RESULTS-There were 3,128 LGS events during the 2,493 days evaluated. The median duration was 11.2 min, and 36% of events occurred overnight. There were 126 full 2-h suspend events that occurred overnight with no patient response, occurring before 3:00 A.M. For these events, the mean sensor glucose at the end of the 2-h suspend period was 99 +/- 6 mg/dL ([means +/- SE] 5.5 +/- 0.3 mmol/L). The mean sensor glucose 2 h after insulin delivery resumed was 155 +/- 10 mg/dL (8.6 +/- 0.6 mmol/L). There were no episodes of severe hypoglycemia or diabetic ketoacidosis. CONCLUSIONS-Analyses of sensor glucose patterns following insulin suspension activated by LGS suggest that this technology is safe and unlikely to be associated with adverse outcomes.
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