Journal
DIABETES CARE
Volume 34, Issue 12, Pages 2551-2554Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc11-0652
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Funding
- INSERM
- Caisse nationale de l'assurance maladie des travailleurs salaries (CNAMTS)
- Lilly
- Novartis Pharma
- sanofi-aventis
- Association Diabete Risque Vasculaire
- Federation Francaise de Cardiologie
- La Fondation de France
- Association de Langue Francaise pour l'Etude du Diabete et des Maladies Metaboliques (ALFEDIAM)/Societe Francophone de Diabetologie
- L'Office national interprofessionnel des vins (ONI-VINS)
- Ardix Medical
- Bayer Diagnostics
- Becton Dickinson
- Cardionics
- Merck Sante
- Novo Nordisk
- Pierre Fabre
- Roche
- Topcon
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OBJECTIVE-Water intake alters vasopressin secretion. Recent findings reveal an independent association between plasma copeptin, a surrogate for vasopressin, and risk of diabetes. RESEARCH DESIGN AND METHODS-Participants were 3,615 middle-aged men and women, with normal baseline fasting glycemia (FG), who were recruited in a 9-year follow-up study. Odds ratios (ORs) and 95% CIs for the incidence of hyperglycemia (FG >= 6.1 mmol/L or treatment for diabetes) were calculated according to daily water intake classes based on a self-administered questionnaire. RESULTS-During follow-up, there were 565 incident cases of hyperglycemia. After adjustment for confounding factors, ORs (95% CIs) for hyperglycemia associated with classes of water intake (<0.5 L, n = 677; 0.5 to <1.0 L, n = 1,754; and >1.0 L, n = 1,184) were 1.00, 0.68 (0.52-0.89), and 0.79 (0.59-1.05), respectively (P = 0.016). CONCLUSIONS-Self-reported water intake was inversely and independently associated with the risk of developing hyperglycemia.
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