Journal
DIABETES CARE
Volume 35, Issue 2, Pages 363-366Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc11-1328
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Funding
- Novo Nordisk
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Swedish Diabetes Association
- Department of Veterans Affairs
- Doris Duke Charitable Foundation
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health
- NIDDK
- Indian Health Service
- National Center for Research Resources
- Office of Research on Minority Health
- National Institute of Child Health and Human Development
- National Institute on Aging
- Centers for Disease Control and Prevention
- Office of Research on Women's Health
- American Diabetes Association
- Henry M. Jackson Foundation
- McKesson BioServices Corporation
- Matthews Media Group
- [R01 DK-072041-02]
- Novo Nordisk Fonden [NNF11OC1014855] Funding Source: researchfish
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OBJECTIVE-We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight-loss inducing interventions (lifestyle and metformin) versus placebo. RESEARCH DESIGN AND METHODS-Sixteen obesity-predisposing single nucleotide polymorphisms (SNPs) were tested for association with short-term (baseline to 6 months) and long-term (baseline to 2 years) weight loss and weight regain (6 months to study end). RESULTS-Irrespective of treatment, the Ala12 allele at PPARG associated with short- and long-term weight loss (-0.63 and -0.93 kg/allele, P <= 0.005, respectively). Gene-treatment interactions were observed for short-term (LYPLAL1 rs2605100, P-lifestyle*SNP = 0.032; GNPDA2 rs10938397, P-lifestyle*SNP = 0.016; MTCH2 rs10838738, P-lifestyle*SNP = 0.022) and long-term (NEGR1 rs2815752, P-metformin*SNP = 0.028; FTO rs9939609, P-lifestyle*SNP = 0.044) weight loss. Three of 16 SNPs were associated with weight regain (NEGR1 rs2815752, BDNF rs6265, PPARG rs1801282), irrespective of treatment. TMEM18 rs6548238 and KTCD15 rs29941 showed treatment-specific effects (P-lifestyle*SNP < 0.05). CONCLUSIONS-Genetic information may help identify people who require additional support to maintain reduced weight after clinical intervention.
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