Diabetic Peripheral Neuropathy Is Associated With Increased Arterial Stiffness Without Changes in Carotid Intima-Media Thickness in Type 2 Diabetes

OBJECTIVE-This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima media thickness (IMT). RESEARCH DESIGN AND METHODS-We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS-Patients with DPN had higher CAV1 than those without DPN in multivariate-adjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In the multivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% Cl 1.13-1.65], P = 0.001). CONCLUSIONS-DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.