Journal
DIABETES CARE
Volume 34, Issue 5, Pages 1214-1218Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc10-2313
Keywords
-
Categories
Funding
- National Prevention Research Initiative
- British Heart Foundation
- Cancer Research UK
- Department of Health
- Economic and Social Research Council
- Medical Research Council
- Research and Development Office for the Northern Ireland Health and Social Services
- Chief Scientist Office
- Scottish Executive Health Department
- Welsh Assembly Government
- World Cancer Research Fund
- NHS Lothian
- NHS Greater Glasgow Clyde RD
- Chief Scientist Office, NHS Health Scotland, and NHS National Services for Scotland
- Diabetes UK
- MRC [G0501310, G0800803] Funding Source: UKRI
- Medical Research Council [G0501310, G0800803] Funding Source: researchfish
Ask authors/readers for more resources
OBJECTIVE-To investigate the independent contributions of waist circumference, physical activity, and sedentary behavior on glycemia in South Asians living in Scotland. RESEARCH DESIGN AND METHODS-Participants were 1,228 (523 men and 705 women) adults of Indian or Pakistani origin screened for the Prevention of Type 2 Diabetes and Obesity in South Asians (PODOSA) trial. All undertook an oral glucose tolerance test, had physical activity and sitting time assessed by International Physical Activity Questionnaire, and had waist circumference measured. RESULTS-Mean +/- SD age and waist circumference were 49.8 +/- 10.1 years and 99.2 +/- 10.2 cm, respectively. One hundred ninety-one participants had impaired fasting glycemia or impaired glucose tolerance, and 97 had possible type 2 diabetes. In multivariate regression analysis, ay (0.012 mmol.L-1.year [95% CI 0.006-0.017]) and waist circumference (0.018 mmol.L-1.cm(-1) [0.012-0.024]) were significantly independently associated with fasting glucose concentration, and age (0.032 mmol.L-1.year(-1) [0.016-0.049]), waist (0.057 mmolL(-1).cm(-1) [0.040-0.074]), and sitting time (0.097 mmol.L-1.h(-1).day(-1) [0.036-0.158]) were significantly independently associated with 2-h glucose concentration. Vigorous activity time had a borderline significant association with 2-h glucose concentration (-0.819 mmol.L-1.h(-1).day-1 [-1.672 to 0.034]) in the multivariate model. CONCLUSIONS-These data highlight an important relationship between sitting time and 2-h glucose levels in U.K. South Asians, independent of physical activity and waist circumference. Although the data are cross-sectional and thus do not permit firm conclusions about causality to be drawn, the results suggest that further study investigating the effects of sitting time on glycemia and other aspects of metabolic risk in South Asian populations is warranted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available