Journal
DIABETES CARE
Volume 33, Issue 9, Pages 1962-1963Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc10-0814
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- Ministero Universita e Ricerca Scientifica
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OBJECTIVE - We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type I diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS - Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 mu g/day calcitriol or placebo and followed-up for 2 years. RESULTS - At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point. CONCLUSIONS - At the doses used, calcitriol is ineffective in protecting beta-cell function in subjects (including children) with recent-onset type I diabetes and high C-peptide at diagnosis.
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