Journal
DIABETES CARE
Volume 33, Issue 6, Pages 1385-1388Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc09-2353
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Funding
- Santa Maria Research Institute, Arequipa, Peru
- National Institutes of Health (NIH)
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases
- NIH Office of Research on Women's Health through the International Clinical Research Fellows Program at Vanderbilt University [R24 TW007988]
- NIH [RO1-HL080076]
- American Heart Association National Research [0885031N]
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OBJECTIVE - We aimed to establish optimal definitions for abdominal obesity and metabolic syndrome (MetS) among Andean adults. RESEARCH DESIGN AND METHODS - Among 1,448 Andean adults, we assessed the relationship between waist circumference and subclinical vascular disease assessed by carotid intima-media thickness (cIMT) and manifest cardiovascular disease (M-CVD). RESULTS - Optimal waist circumference cutoffs to classify individuals with abnormal cIMT or M-CVD were >97 and >87 cm in men and women, respectively. With these cutoffs, there was substantial disagreement between the original American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) and the recently updated MetS definition, particularly among men (kappa = 0.85). Subjects with MetS identified by the updated definition but not meeting the original AHA/NHLBI MetS criteria demonstrated significantly increased cIMT (P < 0.001) compared with subjects who did not meet the MetS criteria by either definition. CONCLUSIONS - Our findings support the use of ethnic-specific waist circumference cutoffs and the updated MetS definition in Andean adults.
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