Journal
DIABETES CARE
Volume 32, Issue 10, Pages 1904-1906Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc09-0663
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Funding
- Research Council of Norway [135893/330, 155300/320, 156477/730, 166515/V50]
- Norwegian Diabetes Association, the Children With Diabetes Foundation [Food-CT-2005-016320]
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OBJECTIVE - To assess whether maternal BMI before pregnancy and weight gain during pregnancy predicted the risk of islet autoimmunity in genetically susceptible children. RESEARCH DESIGH AHD METHODS - Of 46,939 newborns screened for the high-risk HLA genotype DR4-DQ8/DR3-DQ2, 1,003 were positive and 885 were followed with serial blood samples tested for autoantibodies to insulin, GAD, and insulinoma-associated protein 2 (IA2). The end point was defined as repeated positivity for two or three autoantibodies or the onset of type I diabetes (islet autoimmunity). RESULTS - Thirty-six children developed islet autoimmunity, of whom 10 developed type I diabetes. Both maternal BMI >= 30 kg/m(2) before pregnancy and maternal weight gain >= 15 kg predicted the increased risk of islet autoimmunity (hazard ratio [HR] 2.5, P = 0.023, and HR 2.5, P = 0.015, respectively), independent of maternal diabetes. CONCLUSIONS - Maternal weight may predict risk of islet autoimmunity in offspring with a high genetic susceptibility for type I diabetes.
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