Journal
DIABETES CARE
Volume 32, Issue 7, Pages 1311-1313Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc09-0061
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Funding
- Key Technologies R&D Program of Shandong Province [2006GG2202020]
- National Natural Science Foundation of China [30670874, 30570748, 30871038]
- National Basic Research Program of China [2009CB521904]
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OBJECTIVE - To determine the association of TRIB3 Q84R polymorphism With metabolic syndrome (MetS) and carotid atherosclerosis. RESEARCH DESIGN AND METHODS - A case-control study enrolled 513 Chinese subjects in three groups: control, MetS, and obese. The functional TRIB3 Q84R polymorphism was genotyped among subjects undergoing carotid ultrasonography. The clinical and biochemical characteristics were determined. RESULTS - For individuals with the TRIB3 R84 allele, the odds ratio for developing MetS was 2.349 (P = 0.018), abdominal obesity 2.351. (P = 0.012), hypertriglyceridemia 2.314 (P = 0.00003), and insulin resistance 1.697 (P = 0.023). Likewise, the odds ratio for individuals with the TRIB3 R84 allele to develop thickened intima-media thickness was 2.208 (P = 0.040). CONCLUSIONS - individuals With the functional TRIB3 Q84R polymorphism are at risk for MetS. The TRIB3 R84 allele especially predisposes to carotid atherosclerosis in part through the effects of abdominal obesity, hypertriglyceridemia, and insulin resistance.
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