Journal
DIABETES CARE
Volume 31, Issue 11, Pages 2092-2096Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc08-1204
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Funding
- U.S. Department of Agriculture
- Agricultural Research Service [58-1950-7-707]
- National Institutes of Health [AG14759, HL69272, TH32, HL69772-01A1, AR38460]
- Ministry of Education, Culture, Sports and Technology of Japan
- American Diabetes Association
- National Institute of Diabetes and Digestive and Kidney Diseases [K24 DK080140]
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OBJECTIVE - Vitamin K has a potentially beneficial role in insulin resistance, but evidence is limited in humans. We tested the hypothesis that vitamin K supplementation for 36 months will improve insulin resistance in older men and women. RESEARCH DESIGN AND METHODS - This was an ancillary study of a 36-month, randomized, double-blind, controlled trial designed to assess the impact of Supplementation with 500 mu g/day phylloquinone on bone loss. Study participants were older nondiabetic men and women (n = 355; aged 60-80 years; 60% women). The primary outcome of this study was insulin resistance as measured by homeostasis model assessment (HOMA-IR) at 36 months. Fasting plasma insulin and glucose were examined as the secondary outcomes. RESULTS - The effect of 36-month vitamin K supplementation on HOMA-IR differed by sex (sex X treatment interaction P = 0.02). HOMA-IR was statistically significantly lower at the 36-month visit among men in the supplement group versus the men in the control group (P = 0.01) after adjustment for baseline HOMA-IR, BMI, and body weight change. There were no statistically significant differences in outcome measures between intervention groups in women. CONCLUSIONS - Vitamin K supplementation for 36 months at doses attainable in the diet may reduce progression of insulin resistance in older men.
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