Journal
DIABETES CARE
Volume 32, Issue 1, Pages 126-128Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc08-1054
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [KFO 152]
- Atherobesity [FA476/4-1 (TP4), BL833/1-1 (TP3)]
- Deutsche Diabetes-Stiftung
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OBJECTIVE - To investigate renal elimination of the adipokine fibroblast growth factor 21 (FGF21) by determining circulating FGF21 levels in Patients on chronic hemodialysis (CD) as compared with control subjects with a glomerular filtration rate (GFR) > 50 ml/min. RESEARCH DESIGN AND METHODS - FGF21 was determined by enzyme-linked immunosorbent assay in control (n = 60) and CD (n = 60) patients and correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups. RESULTS - Median serum FGF21 levels were > 15-fold higher in CD patients (3,710.6 ng/l) than in subjects with a GFR > 50 ml/min (201.9 ng/l) (P < 0.001). Furthermore, serum creatinine positively and GFR negatively predicted FGF21 concentrations in multiple regression analyses in control subjects (P < 0.05). CONCLUSIONS - FGF21 serum levels increase in CD patients and are related to markers of renal function in control subjects
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