Journal
DIABETES & VASCULAR DISEASE RESEARCH
Volume 8, Issue 1, Pages 12-21Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1479164110389625
Keywords
Control; diabetes mellitus; exercise; hyperaemia; muscle
Ask authors/readers for more resources
In this study we tested the hypothesis that type 2 diabetes impairs the dynamic response of leg vascular conductance (LVC) during exercise. LVC (leg blood flow/mean arterial pressure) responses were studied during intermittent contractions of the calf muscle in subjects with type 2 diabetes (n = 9), heavy controls (n = I 0) and lean controls (n = 8) using a biexponential function and an estimate of the mean response time (MRT). The time constant of the second phase of LVC was significantly greater in type 2 diabetes (66.4 +/- 29.2 s) than the heavy (22.2 +/- 13.4 s) and lean (21.8 +/- 9.3 s) controls, resulting in a significantly greater MRT in the diabetic group (median [IQR] = 30.7 [24.6-46.5] s versus 16.3 [4.3-23.2] s and 18.4 [13.7-19.3] s). These data support the hypothesis and suggest that a slowed hyperaemic response in the exercising limb might contribute to exercise intolerance in diabetic subjects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available