Journal
DIABETES & VASCULAR DISEASE RESEARCH
Volume 6, Issue 1, Pages 15-20Publisher
SAGE PUBLICATIONS LTD
DOI: 10.3132/dvdr.2009.003
Keywords
diabetes; glucose intolerance; insulin resistance; low grade inflammation; obesity; risk marker; sCD36
Funding
- NovoNordisk Foundation
- Danish Diabetes Association
- EU [COST-B17]
- CIBER Fisiopatologia de la Obesidad y Nutricion [CB06/03/0003]
- Ministry of Science and Innovation of Spain.
- [SAF2008-02073]
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Recently, soluble CD36 (sCD36) levels were reported to be elevated in type 2 diabetes, and to be tightly correlated with insulin resistance. Our aim was to obtain further insight into the relationship between insulin sensitivity, low-grade inflammation and sCD36. We studied glucose-tolerant (n=90) and glucose-intolerant (n=57) moderately obese men. Insulin sensitivity was measured by the frequent sample intravenous glucose tolerance test, and sCD36 by an in-house ELISA assay. In glucose-intolerant subjects, sCD36 was negatively associated with insulin sensitivity and positively with interleukin-6 (IL-6), fasting glucose, fasting triglycerides, fat-free mass and platelet count. On multiple linear regression analyses, insulin sensitivity contributed 22% of sCD36 variance, independent of age, body mass index (BMI) and IL-6, in glucose-intolerant subjects. The level of sCD36 in subjects with glycosylated haemoglobin (HbA(1C)) above the mean was higher than in those with HbA(1C) values below the mean. Insulin sensitivity is a predictor of sCD36 in men with impaired glucose tolerance. IL-6 is related to sCD36 but does not predict sCD36 independent of insulin sensitivity and BMI.
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