Journal
DIABETES & VASCULAR DISEASE RESEARCH
Volume 6, Issue 4, Pages 291-296Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1479164109341689
Keywords
adhesion molecules; endothelium; exercise training; risk factor
Funding
- Nordea Foundation
- Novo Nordisk Foundation
- Danish Diabetes Association
- Danish Heart Foundation
- Jacob Madsens and Olga Madsens Foundation
- Foundation of 1870
- Danish National Research Council
- Aase and Ejnar Danielsens Foundation
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Patients with T2DM have an increased risk of CVD. Prevention of CVD represents the major goal of all treatment of T2DM, and early intervention in those patients at particularly high risk is important. We measured the insulin sensitivity and plasma biomarkers of CVD to determine whether a home-based exercise training program improves biomarker levels and insulin sensitivity. Patients with T2DM (n=12), IGT (n=4) and healthy control subjects (n=9) were studied before and after eight weeks of exercise training by rowing ergometry at 65-70% of peak oxygen uptake. Conclusions: 1) patients with T2DM have elevated plasma concentrations of CVD biomarkers compared to the matched control and IGT groups; 2) a moderate to vigorous intensity home-based training program did not reduce plasma concentrations of these CVD markers; 3) insulin sensitivity improved as a result of exercise training in the control group, but not in the T2DM group.
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