Journal
DIABETES & VASCULAR DISEASE RESEARCH
Volume 5, Issue 1, Pages 59-66Publisher
SAGE PUBLICATIONS LTD
DOI: 10.3132/dvdr.2008.011
Keywords
angiotensin-converting enzyme (ACE) inhibitor; angiotensin receptor blocker (ARB); diabetes; prevention; renin-angiotensin-aldosterone system
Funding
- GlaxoSmithKline
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Type 2 diabetes mellitus (DM) is increasing around the world, and the public health impact of DM, driven largely by cardiovascular disease complications, underpins the importance of continued efforts toward primary prevention of DM. Only a few interventions have been shown to prevent DM, with none of them yet proven to improve cardiovascular risk commensurately. Accumulating evidence suggest that drugs that block the renin-angiotensin-aldosterone system (RAAS), many of which have proven cardiovascular disease (CVD) benefit, also have favourable effects on parameters of glucose metabolism and incident diabetes. Here we review the evidence accumulated to date from animal studies, clinical mechanistic studies and clinical trials regarding the effect of RAAS inhibition and incident DM.
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