Journal
DIABETES & METABOLISM
Volume 40, Issue 2, Pages 87-94Publisher
MASSON EDITEUR
DOI: 10.1016/j.diabet.2013.11.003
Keywords
Obesity; Bariatric surgery; Gastric bypass; Diabetes; Gut peptides
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Funding
- NIDDK NIH HHS [R01 DK067561, T32 DK007559] Funding Source: Medline
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Severe obesity is a preeminent health care problem that impacts overall health and survival. The most effective treatment for severe obesity is bariatric surgery, an intervention that not only maintains long-term weight loss but also is associated with improvement or remission of several comorbidies including type 2 diabetes mellitus. Some weight loss surgeries modify the gastrointestinal anatomy and physiology, including the secretions and actions of gut peptides. This review describes how bariatric surgery alters the patterns of gastrointestinal motility, nutrient digestion and absorption, gut peptide release, bile acids and the gut microflora, and how these changes alter energy homeostasis and glucose metabolism. (C) 2013 Elsevier Masson SAS. All rights reserved.
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