Journal
DIABETES
Volume 64, Issue 1, Pages 291-298Publisher
AMER DIABETES ASSOC
DOI: 10.2337/db14-0563
Keywords
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Categories
Funding
- Korea Centers for Disease Control and Prevention [4845-301, 4851-302, 4851-307]
- Korea National Institute of Health, the Republic of Korea [2012-N73002-00]
- National Research Foundation of Korea - Korean government (Ministry of Education, Science and Technology) [2012R1A2A1A03006155]
- U.S. National Institutes of Health (NIH) [DK078150, TW05596, HL085144, TW008288]
- Academy of Finland [124243]
- Finnish Heart Foundation
- Finnish Diabetes Foundation
- Tekes [1510/31/06]
- Commission of the European Community [HEALTH-F2-2007-201681]
- NIH [DK093757, DK072193, DK062370, 1Z01 HG000024, R01CA064277, R01CA082729, R37CA070867, R01CA124558, R01CA148667, R01CA122364, R01CA122756, R01CA137013]
- Vanderbilt University School of Medicine
- National 973 Program [2011CB504001]
- National Natural Science Foundation of China [81170735, 81322010]
- Excellent Young Medical Expert of Shanghai [XYQ2011041]
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- National 863 Program [2012AA02A509]
- Shanghai Rising Star Program [12QH1401700]
- Shanghai Talent Development Grant [2012041]
- National Young Top Talent Support Program
- Hong Kong Foundation for Research and Development in Diabetes
- Chinese University of Hong Kong
- Hong Kong government Research Grant Committee Central Allocation Scheme [CUHK 1/04C]
- Theme-Based Research Scheme [T12-402/13-N]
- Innovation and Technology Fund [ITS/088/08, ITS/487/09FP]
- Chinese University Direct Grant
- NIH from the National Institute of Diabetes and Digestive and Kidney Diseases [NIH-RFA DK-085545-01]
- NIH National Heart, Lung, and Blood Institute [U01HL072507, R01HL087263, R01HL090682]
- [RR20649]
- [ES10126]
- [DK56350]
- FOGARTY INTERNATIONAL CENTER [R01TW005596, R01TW008288] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R01CA124558, UM1CA182910, R01CA082729, R01CA148667, R01CA122756, R01CA064277, R37CA070867, R01CA122364, R01CA137013, UM1CA173640] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR020649] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL072507, R01HL087263, R01HL090682, R01HL085144] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [Z01HG000024] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R56DK062370, R01DK093757, R01DK072193, R01DK078150, P30DK056350, R01DK062370, U01DK085545, U01DK062370] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES010126] Funding Source: NIH RePORTER
- Grants-in-Aid for Scientific Research [221S0001] Funding Source: KAKEN
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Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
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