Journal
DIABETES
Volume 63, Issue 10, Pages 3253-3265Publisher
AMER DIABETES ASSOC
DOI: 10.2337/db13-1885
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Funding
- European Union FP7 project DIABAT [HEALTH-F2-2011-278373]
- European Union FP7 project METABOSTEM [PC169-GA-2011-293720]
- ANR Safe
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The presence of brown adipose tissue (BAT) in human adults opens attractive perspectives to treat metabolic disorders. Indeed, BAT dissipates energy as heat via uncoupling protein (UCP)1. Brown adipocytes are located in specific deposits or can emerge among white fat through the so-called browning process. Although numerous inducers have been shown to drive this process, no study has investigated whether it could be controlled by specific metabolites. Here, we show that lactate, an important metabolic intermediate, induces browning of murine white adipose cells with expression of functional UCP1. Lactate-induced browning also occurs in human cells and in vivo. Lactate controls Ucpl expression independently of hypoxia-inducible factor-1 alpha and PPAR alpha pathways but requires active PPAR gamma signaling. We demonstrate that the lactate effect on Ucpl is mediated by intracellular redox modifications as a result of lactate transport through monocarboxylate transporters. Further, the ketone body beta-hydroxybutyrate, another metabolite that impacts redox state, is also a strong browning inducer. Because this redox-dependent increase in Ucpl expression promotes an oxidative phenotype with mitochondria, browning appears as an adaptive mechanism to alleviate redox pressure. Our findings open new perspectives for the control of adipose tissue browning and its physiological relevance.
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